Extracellular matrix proteins: A positive feedback loop in lung fibrosis?
نویسندگان
چکیده
منابع مشابه
Fibrotic extracellular matrix activates a profibrotic positive feedback loop.
Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF are not well defined. Here, we examined how the interplay between the ECM and fibroblasts affects ...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2014
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2013.11.002